Ingredients: PediaVance Apple & Grape Flavors

PediaVance® is Made with Organic Ingredients

While the leading and store brands use artificial sweeteners, colors and flavors, PediaVance® only uses organic and natural ingredients. PediaVance® Oral Electrolyte is approximately 60% organic. Under the USDA organic laws, the minerals (electrolytes) used to prevent dehydration cannot be certified organic. This is because minerals are not agriculturally grown or harvested ingredients. Instead minerals are taken directly from the earth. No chemicals are used to extract or process the minerals. If the minerals could be certified organic, PediaVance® Oral Electrolyte would be considered 80% or greater organic by ingredient weight.

Apple PediaVance® Ingredients:  Water, Organic White Grape Juice Concentrate, Organic Dextrose, Malic Acid, Natural Flavor, Sodium Bisulfate, Potassium Citrate, Sodium Chloride, Sodium Citrate, Steviol Glycosides, Caramel Color, Zinc Gluconate.

Grape PediaVance® Ingredients: Water, Organic White Grape Juice Concentrate, Organic Dextrose, Malic Acid, Natural Flavor, Sodium Bisulfate, Natural Color, Potassium Citrate, Sodium Chloride, Sodium Citrate, Steviol Glycosides, Zinc Gluconate.

PediaVance® is made without GMO ingredients. This product does not contain corn, gluten, preservatives or alcohol. It is certified kosher. No BPA used in packaging.

Water

Filtered, purified water is used in the manufacturing process for PediaVance®. 

It is extremely important to note that each PediaVance® liquid stick MUST be reconstituted only with water. Water from a municipal water supply or bottled plain water can be used.  If the water source is well water, please consult with your healthcare provider to determine if another water source should be used.

Do NOT mix with household beverages such as soda, juice or sports beverages as this will result in a carbohydrate and electrolyte composition unsuitable for rehydration and can cause a worsening of symptoms. Do NOT vary from the recommended water to electrolyte solution ratio as noted on the PediaVance® package instructions unless otherwise specified by a healthcare professional.  Each tube of PediaVance® should be added to 4 fluid ounces of water.

Carbohydrates

Brand Carbohydrate Source
Pediavance® Organic Dextrose,
Organic White Grape Juice Concentrate
Pedialyte® Dextrose
Generic Pediatric Electrolyte Solution
(i.e. CVS, Walgreens, Others)
Dextrose, Fructose


The organic carbohydrate composition of PediaVance® has been specifically designed to meet the requirements of an oral rehydration solution to prevent and treat mild to moderate dehydration.  An appropriate combination in the proper amounts of organic dextrose (also known as glucose), derived from organic tapioca, and organic white grape juice concentrate is used to meet carbohydrate requirements. 

The organic dextrose is used by the body as a ready source of glucose for the body’s important glucose-sodium cotransport system.  This combination of glucose and sodium in the intestinal tract promotes the absorption of water into the body’s bloodstream to help maintain hydration. 

The organic white grape juice concentrate provides glucose and a secondary source of carbohydrate called fructose, also known as fruit sugar.  Although the primary carbohydrate in an oral electrolyte solution is glucose to support the glucose-sodium cotransport system, small amounts of fructose have been shown over the years to be safe and effective.1  The naturally occurring fructose in organic white grape juice concentrate also works with the other flavor ingredients in PediaVance® to make the solution tastier.   Also, white grape juice has been recommended as the first fruit juice to introduce to children because it does not contain the sugar alcohol called sorbitol.2,3  Sorbitol is known to attract water into the intestinal tract and is useful for treatment of constipation but is not desirable in situations, such as diarrhea or excess sweating, where water needs to be absorbed from the intestinal tract into the bloodstream to maintain hydration status.  Also, white grape juice has been found to be well tolerated in children recovering from diarrhea because it has the right combination of carbohydrates without the presence of sorbitol.

Many oral rehydration solutions are rejected by infants, children, and adults because of their unpleasant and salty taste.  Organic white grape juice concentrate helps to provide the pleasant all-natural flavoring in PediaVance® in conjunction with steviol glycosides and natural flavors resulting in a tasty oral rehydration solution.

The combination of organic dextrose and organic white grape juice in PediaVance® results in an overall and appropriate carbohydrate composition of 2.4 grams of glucose and 0.6 grams of fructose per 4 fluid ounces when prepared according to package instructions.  The ratio of glucose to sodium in PediaVance® is 2.5 and is also appropriate for an oral rehydration solution to support the glucose-sodium cotransport system.

References:

1  Listernick R, Zieser E, Davis AT.  Outpatient oral rehydration in the United States.  American Journal of Diseases of Children.  1986; 140:211-215. 

2  Nobigrot T, Chasalow FI, Lifshitz F.  Carbohydrate absorption from one serving of fruit juice in young chidren: age and carbohydrate effects.  Journal of the American College of Nutrition.  1997; 16:152-158.

3 Moukarzel AA, Lesicka H, Ament ME.  Irritable bowel syndrome and nonspecific diarrhea in infancy and childhood relationship with juice malabsorption.  Clinical Pediatrics.   2002; 41:145-150.

4 Ribeiro H, Ribeiro TC, Valois S, et al.  Incomplete carbohydrate absorption from fruit juice consumption after acute diarrhea.  Journal of Pediatrics.  2001; 139:325-327.

Electrolytes

Brand Electrolyte Source
PediaVance® Potassium Citrate, Sodium Chloride,
Sodium Citrate
Pedialyte® Potassium Citrate, Sodium Chloride,
Sodium Citrate
Generic Pediatric Electrolyte Solution
(i.e. CVS, Walgreens, Others)
Potassium Citrate, Sodium Chloride,
Sodium Citrate

Sodium, potassium and chloride are called electrolytes. Electrolytes are mineral substances that become

Electrolytes are mineral substances that become chemical ions in a solution and acquire the capacity to conduct electricity.  The balance of the electrolytes in the body is essential for the normal functioning of all body cells and organs.  Sodium in combination with glucose aids the absorption of water from the intestinal tract into the bloodstream and from the bloodstream into body cells.  This helps to retain fluids in the body and prevent dehydration.  Potassium works with sodium to help regulate fluid balance within the body’s cells.  Chloride helps to maintain the acid-base balance of the body fluids and prevents acidosis.  These electrolytes are important to include in the proper amounts in an oral rehydration solution to replace stool losses or losses from vomiting or excessive sweating and to help maintain hydration.

Sodium needs in PediaVance® are met by sodium bisulfate, sodium chloride, and sodium citrate and potassium citrate meets potassium needs.  Sodium chloride also helps to meet chloride needs.  Sodium chloride is salt.  Sodium bisulfate helps to ensure an appropriate acid-base balance and also helps to prevent an acidic or sour taste.  Sodium bisulfate does not contribute to any sulfites that may be of concern to individuals with an allergy to sulfites.  Sodium citrate and potassium citrate are rapidly absorbed in the intestinal tract when given orally and help to make the urine less acidic preventing metabolic acidosis.  The use of potassium citrate as a good source of potassium in oral rehydration solutions has been well documented.This combination of electrolyte ingredients provides the required sodium, potassium and chloride needed for an oral rehydration solution. 

There are some individuals who will have an allergic reaction to “sulfites” which are used as common preservatives.  Sodium bisulfate is different and not a “sulfite” nor will it be converted by the body to a sulfite.

Per 8 ounce serving when prepared according to package instructions, PediaVance® provides:

  • Sodium – 244 milligrams (10.6 milliEquivalents)
  • Potassium – 184 milligrams (4.7 milliEquivalents)
  • Chloride – 294 milligrams (8.3 milliEquivalents)

1 Islam MR.  Can potassium citrate replace sodium bicarbonate and potassium chloride in oral rehydration solutions?  Archives of Diseases in Childhood.  1985; 60:852-855.

Malic Acid

Malic acid is naturally found in apples, grapes, and other fruits.  It is used in a wide range of food products as a flavoring agent.  The role of malic acid in PediaVance® is to contribute to the product’s pleasant apple or grape taste. 

Osmolality

The movement of water and electrolytes and glucose across the intestinal tract and into the bloodstream is known as osmosis.  Osmolality is a measure of chemical particles in a solution.  The normal values for the osmolality of the serum in blood range from 275 to 295 milliOsmoles (mOsm) per kilogram (kg) of water.  The osmolality of blood serum increases with dehydration and decreases with over-hydration.  The goal of an oral electrolyte solution is for the solution to have an osmolality close to that of blood serum which helps to promote nutrient absorption from the intestinal tract into the bloodstream and from the bloodstream into the body’s cells reducing stool volume, vomiting, and the need for intravenous (IV) therapy.

The osmolality of Pediavance® is 270 mOsm per kilogram of water, an appropriate value for an oral rehydration solution.

Sweeteners, Color, & Flavor

Brand Color Flavor Sweetener
PediaVance® Fruit and vegetable juice (grape flavor), Caramel
(apple flavor)
Natural Flavors Organic White Grape Juice Concentrate, Stevia leaf extract
Pedialyte® Red 40 & Blue 1
(grape flavor), Yellow 6
(fruit flavor)
Artificial grape flavor; Natural and artificial flavors Sucralose*, Acesulfame, Potassium**
Generic Pediatric Electrolyte Solution
(i.e. CVS, Walgreens, Others)
Red 40 & Blue 1
(grape flavor), Yellow 6
(fruit flavor)
Natural and artificial flavors Sucralose*, Acesulfame, Potassium**

 

PediaVance® Electrolyte is the only electrolyte solution that does not contain artificial sweeteners, colors or flavors:

Sweeteners 
The carbohydrates used in PediaVance® serve a dual purpose. First, the carbohydrates provide the sweetness needed to cover the off flavors of the minerals (electrolytes) used in all electrolyte solutions. Also, the carbohydrates work together with the sodium to move water out of the intestinal tract and into the body, thus promoting hydration. PediaVance® contains organic white grape juice and organic dextrose as its source of carbohydrate and sweetener. Other natural ingredients that aid in the flavoring of PediaVance® include lactic acid to add a pleasant but not too tart taste and stevia leaf extract to provide sweetness for a delicious taste acceptable to infants and children without the use of artificial sweeteners.

The leading brand Pedialyte® uses sucralose as its carbohydrate, which is an artificial sweetener sold under the Splenda® brand name. The various store branded electrolyte solutions use the artificial sweetener acesulfame potassium, which is sold under the brand name Sunett® or Sweet One®.

Flavorings

The flavoring system in an oral electrolyte solution is critical to ensure that the solution will be accepted by an infant and young child.  If the child will not drink the oral electrolyte solution, dehydration can become a serious problem requiring hospitalization and use of an intravenous (IV) solution to achieve hydration.

PediaVance® has a unique flavoring system comprised of organic white grape juice, steviol glycosides, malic acid, and natural flavors.  This combination of ingredients provides a pleasant but not too tart grape or apple taste.  No artificial sweeteners or flavoring agents are used in PediaVance®.

Coloring

Apple flavored PediaVance® contains caramel color.  The natural caramel coloring is processed by heating brown sugar and diluting the concentrated caramel to create the apple-like color.  No harsh chemicals are used to obtain the caramel coloring.  Also, no milk or dairy-based ingredients are used to make the caramel coloring.   The small amount of caramel color used to give PediaVance® its apple juice cover does not contribute to its carbohydrate or sugar content.   

Grape flavored PediaVance® contains fruit and vegetable juices for color. The natural fruit and vegetable color used in grape PediaVance is a proprietary blend of natural extracts that could be derived from beets, grape skin, elderberry, purple potatoes, and/or purple carrots.  No chemicals are used in the processing of this coloring agent. 

Pediavance® contains no artificial colors or dyes.

Pedialyte® is a registered trademark of Abbott Laboratories
*Splenda is a registered trademark of McNeil Nutritionals, LLC for the sweetener sucralose
**Sunett is a registered trademark of Nutrinova for the sweetener acesulfame K.
*** Sweet One is a registered trademark of Stadt Holdings Corporation for the sweetener acesulfame potassium.

Zinc

Zinc is an essential trace mineral needed by the body to:

  • Stimulate the activity of many enzymes
  • Maintain a healthy immune system
  • Properly make DHA
  • Aid wound healing
  • Serve as an antioxidant
  • Promote good growth during childhood

During an illness causing diarrhea, the intestinal cells secrete electrolytes, primarily sodium, and water into the intestinal tract resulting in the loss of water and electrolytes in the watery stools.  Zinc helps to protect the intestinal cells and promote absorption of these nutrients resulting in a decrease in the duration and severity of the diarrhea.1,2,3,4   Because zinc promotes the absorption of electrolytes in the intestinal tract, its addition in an oral electrolyte solution helps to prevent dehydration.

PediaVance® contains 1.85 milligrams of zinc in the form of zinc gluconate per 8 fluid ounce serving.

1 Walker CLF, Fontaine O, Young MW, Black RE.  Zinc and low osmolarity oral rehydration salts for diarrhea: a renewed call to action.  Bulletin of the World Health Organization. 2009; 87:780-786.

2Bahl R, Bhandari N, Strand T, et al.  Efficacy of zinc-fortified oral rehydration solution in 6- to 35-month old children with acute diarrhea.   Journal of Pediatrics.  2002; 141:677-682.

3 Passariello A, Terrin G, DeMarco G, et al.  Efficacy of a new hypotonic oral rehydration solution containing zinc and prebiotics in the treatment of childhood acute diarrhea: a randomized controlled trial.  Journal of Pediatrics.  2011; 158:288-292.

4 Wingertzahn MA, Rehman KU, Altar W, Wapnir RA.  Zinc as a potential enteroprotector in oral rehydration solutions: its role in nitric oxide metabolism.  Pediatric Research.  2003; 53:434-439.

Steviol Glycosides

“Steviol glycosides” is the common name used in the United States for the natural constituents of the plant called Stevia rebaudiana Bertoni, often simply referred to as SteviaSteviol glycosides are Generally Regarded as Safe (GRAS) by the U.S. Food and Drug Administration (FDA).1    Stevia has been used for centuries as a sweetener for foods and beverages and is 250 to 300 times sweeter than table sugar (sucrose).

Steviol glycosides are used as a natural non-caloric sweetener and are not part of the carbohydrate profile for an oral rehydration solution.  Because taste is such an important feature in the acceptability of an oral rehydration solution, especially with children, steviol glycosides sweeten the product without disrupting the important glucose to sodium level required in an oral rehydration product.  Steviol glycosides in conjunction with organic white grape juice concentrate and natural flavors make PediaVance® a pleasant flavored beverage for the prevention or treatment of mild to moderate dehydration.

    1    https://www.accessdata.fda.gov/scripts/fdcc/?set=GRASNotices&sort=GRN_No&order=DESC&startrow=1&type=basic&search=Stevia   Sourced 8-2017

 

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